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It is now possible to map the activity of nearly all the neurons in a vertebrate brain at cellular resolution. What does this mean for neuroscience research and projects like the Brain Activity Map proposal?
In an Article that just went live in Nature Methods, Misha Ahrens and Philipp Keller from HHMI’s Janelia Farm Research Campus used high-speed light sheet microscopy to image the activity of 80% of the neurons in the brain of a fish larva at speeds of a whole brain every 1.3 seconds. This represents—to our knowledge—the first technology that achieves whole brain imaging of a vertebrate brain at cellular resolution with speeds that approximate neural activity patterns and behavior. (...) - by erika pastrana, Nature Methods, 18 Mar 2013
Julien Hering, PhD's insight:
Whole-brain functional imaging at cellular resolution using light-sheet microscopy by Misha B Ahrens & Philipp J Keller in Nature Methods (2013) doi:10.1038/nmeth.2434
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