An optogenetic approach in epilepsy

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[Review] Highlights:

• Optogenetic tools allow selective activation/silencing of specific neuronal populations.
• Inhibitory opsins have been shown to efficiently reduce epileptiform activity in brain slices.
• New strategies for controlling seizures could be explored using optogenetics.
• Technically challenging optimisation of optogenetic approaches.
• Some uncertainty in predicting outcomes of optogenetic interventions on excitability of complex neuronal networks. (...) - by Kokaia Met al., Neuropharmacology, Volume 69, June 2013, Pages 89–95

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