High-fidelity optical reporting of neuronal electrical activity with an ultrafast fluorescent voltage sensor

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In this technical report, St-Pierre and colleagues introduce a new genetically encoded voltage sensor called Accelerated Sensor of Action Potentials 1 (ASAP1), which consists of a circularly permuted GFP inserted in the extracellular voltage-sensing domain of a phosphatase. ASAP1 surpasses existing sensors in reliably detecting single action potentials and tracking subthreshold potentials and high-frequency spike trains. (...) -  by St-Pierre F. et al., Nature Neuroscience 17, 884–889 (2014)

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